HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08046(SMURF1 antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab08046(SMURF1 Antibody) at dilution of 1:50
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes(PubMed:23999003).